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SCIENCE AND TECHNOLOGY

WHAT ARE EXOSOMES ?

BENEV Exosome treatments are based on the most cutting edge scientific biotech breakthrough for skin rejuvenation and regeneration. Exosomes are responsible for cell to cell communication and for facilitating the exchange of RNA and other important proteins between cells (e.g. fibroblasts, keratinocytes, immune cells, etc.), in addition to transferring numerous growth factors and cytokines and genetic materials that have shown signs of tissue repair and improving skin cells. These data coding avatars have been harnessed for our new line of exosome products to promote a more radiant youthful appearance.

WHAT IS EXOSCRT™ ?

Exosome, an 30~200 nm endoplasmic reticulum that is secreted for cell-to-cell communication, plays an important role in influencing the microenvironment around cells, ExoSCRT™ is an innovative technology to separate and refine 0.1% pure exosomes from stem cells and helps the virtualization of natural skin energy by affecting skin cells effectively.

BENEV Exosome Regenerative Complex powered by Exo-SCRT ™ and BENEV Exosome Regenerative Complex + powered by Exo-SCRT™ are post care “topical use” cosmetic solutions. The isolated and purified exosomes in both products have been accepted by the PCPC, and International Cosmetic Ingredient Nomenclature Committee (INC), and the name ‘Human Adipose Stromal Cell Exosomes’ was given and published in the International Cosmetic Ingredient Dictionary and Handbook, known as INCI book. There are at this time no other cosmetic INCI name(s) assigned to exosome products in the market prior to this accomplishment. These products are not drug products. They are not intended to prevent, treat or cure diseases or medical conditions. They are not intended to be injected or delivered intravenously.

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IN VITRO TESTING

HUMAN FIBROBLAST CELL PROLIFERATION

Exosome Regenerative Complex and Exosome Regenerative Complex + powered by ExoSCRT™ promotes skin cell proliferation by up to 80% in a dose-dependent manner. ExoSCRT™ 3 µg/ml 36.1% increase, ExoSCRT ™ 6 µg/ml 84.0% increase, compared against positive control (1% GS).   

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NEGATIVE CONTROL

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1% GROWTH SUPPLEMENTS

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1% GS + ERC 3 uG/ML

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1% GS + ERC 6 uG/ML

ELASTIN INCREASEAD BY ExoSCRT ™

Exosome Regenerative Complex and Exosome Regenerative Complex + powered by

ExoSCRT ™ may increase the elastin amount of human dermal fibroblasts up to 300% in vitro. 

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COLLAGEN INCREASEAD BY ExoSCRT ™

After delivery of BENEV Exosome Regenerative Complex and Exosome Regenerative Complex + powered by ExoSCRT ™ into fibroblasts, neocollagenesis can increase up to 6 folds.

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CELLULAR UPTAKE OF EXOSOMES

Human skin cells easily uptake BENEV Exosome Regenerative Complex and Exosome Regenerative Complex + powered by ExoSCRT ™ which means that stem cell-derived exosomes can message skin cells to “Do Something”.

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IN VIVO TESTING

Exosomes are nano-sized vesicles (30–200 nm) constantly released by almost all cells. The ability of exosomes to travel between cells and deliver their cargo, which includes lipids, proteins, and nucleic acids, makes them an appealing cell-free therapy option to treat multiple diseases. Here, we investigated for the first time whether human adipose tissue-derived mesenchymal stem cell-derived exosomes can ameliorate atopic dermatitis (AD) in an in vivo mouse model. When injected either intravenously (IV) or subcutaneously (SC) into NC/Nga mice treated with house dust mite antigens, ERC-exosomes were found to reduce pathological symptoms such as clinical score, the levels of serum IgE, the number of eosinophils in blood, and the infiltration of mast cells, CD86+, and CD206+ cells in skin lesions. ERC-exosomes also significantly reduced mRNA expression of various inflammatory cytokines such as interleukin (IL)-4, IL-23, IL-31, and tumor necrosis factor  (TNF-) in AD skin lesions of Nc/Nga mice. Taken together, these results suggest that ERC-exosomes can be a novel promising cell-free therapeutic modality for AD treatment. (Byong Seung Cho, Jin Ock Kim, Dae Hyun Ha and Yong Weon - Stem Cell Research Therapy, BioMedCentral.com)

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EXOSOME REGENERATIVE COMPLEX

POWERED by ExoSCRT™

Exosome Regenerative Complex is an intensive dual-action complex formulated to absorb quickly into the skin delivering the concentrated power over 2.5 BILLION STEM CELL DERIVED LYOPHILIZED EXOSOMES, potent GROWTH FACTORS, PEPTIDES, COENZYMES, MINERALS, AMINO ACIDS, and VITAMINS. Our paraben-free, steroid-free, and hypoallergenic patented technologies and ingredients are clinically proven to rejuvenate and regenerate the skin.

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SKIN

Noticeably reduces the appearance of age-related pigment Visibly makes skin appear firmer and more youthful Visibly reduces the appearance of fine lines and wrinkles Hydrates and nourishes the skin

Promotes a more radiant and even-toned complexion

EXOSOME

REGENERATIVE COMPLEX +

EXOSOME

REGENERATIVE COMPLEX

SCALP

Noticeably reduces the appearance of age-related pigment Visibly makes skin appear firmer and more youthful Visibly reduces the appearance of fine lines and wrinkles Hydrates and nourishes the skin

Promotes a more radiant and even-toned complexion 

SKIN

Noticeably reduces the appearance of age-related pigment Visibly makes skin appear firmer and more youthful Visibly reduces the appearance of fine lines and wrinkles Hydrates and nourishes the skin

Promotes a more radiant and even-toned complexion 

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99%

PURE

EXOSOME

INCREASE IN

FIBROBLAST

180%

INCREASE IN

ELASTIN

300%

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BEFORE & AFTER

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POST MICRO NEEDLING

Female | 28

Photo Provided by:

Dr. Diane Duncan .,MD.,F.A.C.S

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POST ERBIUM LASER

Female | 58

Photo Provided by:

Dr. Diane Duncan .,MD.,F.A.C.S

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POST PLASMA

Female | 38

Photo Provided by:

Dr. JD McCoy NMP

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POST PLASMA

Female | 53

Photo Provided by:

Dr. Randy Miller., MD., F.A.C.S

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POST MICRO NEEDLING

Male | 49

Photo Provided by:

Dr. Richard Goldfarb., MD., F.A.C.S

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POST MICRO NEEDLING

Female | 49

Photo Provided by:

Dr. JD McCoy NMP

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POST PLASMA

Female | 57

Photo Provided by:

Dr. Diane Duncan .,MD.,F.A.C.S

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POST MICRO NEEDLING

Female | 49

Photo Provided by:

Dr. Richard Jin., MD., PhD

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POST MICRO NEEDLING

Female | 35

Photo Provided by:

Dr. Richard Jin., MD., PhD

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POST PLASMA

Female | 72

Photo Provided by:

Dr. JD McCoy NMP

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POST PLASMA

Male | 58

Photo Provided by:

Dr. JD McCoy NMP

Patient trial photos (Mei Vu™) were taken before and after a 3 - 5 EXO-XOM FACIAL Clinical Study featured BENEV Exosome Regenerative Complex powered by ExoSCRT TM. Participants experienced  no irritation, and all patients reported that they felt and saw a noticeable and immediate difference in the overall appearance of their skin after just the first treatment, with full results after the 3rd-5th treatment. 

BEFORE & AFTER

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POST MICRO NEEDLING

  • Protocol: 1-month interval

  • Effective in the hair loss (Hair Restoration)

  • Clinical conducted by : Pure Vanity Spa

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POST ERBIUM LASER

  • Protocol : 1 month interval, 6 sessions of treatments

  • Clinical conducted by : Dr. Inigo De Felipe 

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POST MICRO NEEDLING

  • Protocol: 2 sessions of treatments (a day before the hair implantation and during the hair implantation)

  • Patient’s satisfaction index : 10 (out of 10). Product was applied on where hair was collected, and it has improved bleeding and redness.

  • Clinical conducted by : Dr. Asli Berker

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POST MICRO NEEDLING

  • Protocol: 1 week interval, 5 sessions

  • Improvement on the overall hair loss and that of the top of the head

  • Clinical conducted by : Dr. Chang Ro Lee, Leo Clinic

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POST MICRO NEEDLING

  • Protocol: 1 week interval, 5 sessions

  • Improvement of hairline and growth of baby hair on the top of the head

  • Clinical conducted by : Dr. Hwang HeuiLee, Cheongdam NB Clinic

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POST MICRO NEEDLING

  • Protocol: 2 sessions of treatments (a day before the hair implantation and during the hair implantation)

  • Patient’s satisfaction index : 10 (out of 10). Product was applied on where hair was collected, and it has improved bleeding and redness.

  • Clinical conducted by : Dr. Asli Berker